Prevention of calcium-induced membrane structural alterations in erythrocyte membranes by flunarizine
نویسندگان
چکیده
منابع مشابه
ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS
35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the ...
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Erythrocytes have been long considered as "dead" cells with transport of oxygen (O(2)) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions betw...
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The role of biological membranes as a target in biological radiation damage remains unclear. In the present article, we show that the structural, biochemical and biophysical changes of a simple biological membrane, i.e. human erythrocyte membranes, which is altered after exposure, could be studied by membrane mimetics and conventional NMR spectrometers.
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INTRODUCTION Conformations of membrane proteins, membrane fluidity of erythrocytes in patients with AILC were studied with the use of electron paramagnetic resonance and spectrophotometric methods. The concentration of substances reacting with thiobarbituric acid was also determined. The aim of the study was to recognize the nature, level and causes of changes in the structure of erythrocytary ...
متن کاملanticonvulsant therapy-induced alterations in calcium homeostasis
35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. the patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. these changes appear to be related to the anticonvulsant drug taken, in the follo...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1988
ISSN: 0005-2736
DOI: 10.1016/0005-2736(88)90421-x